Which of the following is true regarding Schedule I drugs?

Schedule I drugs are classified as the most tightly controlled substances under the Controlled Substances Act. This classification is due to their high potential for abuse, lack of accepted medical use in the United States, and a lack of accepted safety for use under medical supervision.

The legal framework reflects these characteristics, establishing strict regulations surrounding the manufacture, distribution, and use of Schedule I substances. These drugs cannot be legally prescribed, which underscores their designation as having no accepted therapeutic benefits.

In contrast, the other options do not align with Schedule I definitions; such drugs are not frequently prescribed due to their illegality for medical use and they do not have accepted medical uses, making options related to accepted medical purposes or regulatory oversight inaccurate for this category.