Which of the following is required for a pharmacy to dispense controlled substances?

To dispense controlled substances legally, a pharmacy must obtain a registration from the Drug Enforcement Administration (DEA), which is formalized through the completion of the DEA Form 224. This registration allows the pharmacy to order, receive, and dispense controlled substances in compliance with federal regulations. The DEA Form 224 serves as the official documentation that the pharmacy has been authorized by the DEA to handle these substances, ensuring adherence to laws designed to prevent misuse and trafficking.

While other forms mentioned play key roles in the overall control and regulation of substances, they do not serve the specific purpose of establishing a pharmacy's ability to dispense controlled substances. For instance, DEA 106 is used to report theft or loss of controlled substances, DEA 363 pertains to the registration for narcotic treatment programs, and DEA 222 is a form used specifically for ordering Schedule I and II controlled substances. These forms are important in their own contexts but are not the foundational requirement for a pharmacy's authority to dispense controlled substances.