Which of the following is classified as Schedule III?

The classification of drugs under the Controlled Substances Act is crucial for understanding their legal status, prescribing restrictions, and potential for abuse. Schedule III substances are characterized by having a moderate potential for abuse relative to substances in Schedules I and II, and they may lead to moderate or low physical dependence or high psychological dependence.

Hydrocodone with acetaminophen is classified as a Schedule III substance, as it combines an opioid with a non-opioid analgesic, and is considered to have a lower risk of abuse compared to pure opioids. Schedule III substances can be prescribed and refilled under certain conditions, making them more accessible than those classified under Schedules I and II, which have stricter regulations.

In contrast, the other options listed—hydromorphone, meperidine, and fentanyl—are classified as Schedule II substances. These drugs carry a higher risk of addiction and abuse, warranting tighter control. Schedules are assigned based on the potential for abuse, the accepted medical use in treatment, and safety or dependence potential.

Thus, the classification of hydrocodone with acetaminophen as Schedule III reflects its moderate potential for abuse and its accepted medical use, distinguishing it from the more tightly regulated Schedule II opioids.